Research


Protein Misfolding Diseases.

Dr. Basant kumar Patel

Our research interests includes investigation of molecular mechanisms of protein misfolding and amyloid formation that lead to devastating diseases such as Alzheimer’s, Huntington’s and amyotrophic lateral sclerosis (ALS). Our laboratory uses tools such as the yeast model, biochemistry and biophysics to investigate the misfolding of the implicated proteins into amyloid in these diseases. The ultimate goal is to understand the mechanisms by which cellular factors enhance or mitigate the amyloid formation that may lead to identifying therapeutic targets.

Molecular and cellular biology of DNA damage, recognition and repair.

Dr. Anindya Roy

Our genome is continuously subjected to various harmful insults from nucleic-acid-modifying compounds. The persistent DNA damage induces genome instability associated with cancer. Alkylating agents are one of the significant sources of deleterious DNA damage. Current research focus of my lab is to understand the pathways of repairing these alkyl DNA adducts.

Molecular Virology.

Dr. NK Raghavendra

The focus of research is to biochemically characterize human proteins that influence integration of HIV-1 DNA into human genome. The interaction between viral and human proteins is analyzed in vitro using recombinant proteins. Findings of these studies are applied for designing small molecule inhibitors of the interaction.

Biophysics.

Dr. Thenmalarchelvi Rathinavelan

Our overall focus is on exploring physical principles that govern biological phenomena by employing theoretical/computational, biochemical and structural techniques. Our research area includes, but not limited to, understanding molecular basis of trinucleotide repeat expansion disorders, multi drug resistance in Gram-negative bacteria and development of efficient theoretical methods to understand biomacromolecular structure, dynamics, function and interaction.

Structural Biology, Epigenetic and Enzyme engineering.

Dr. Rajkumar Eerappa

Structural, biochemical and computational characterization of modular proteins involved in epigenetic gene regulation, DNA repair and chromatin organization

Ion channel Biology, Molecular Mechanisms of Diseases using Zebra-fish Animal Model.

Dr. Anamika Bhargava

Research in our lab focuses on the role of ion channels in health and disease. We use varied techniques like molecular biology, biochemistry, electrophysiology and microscopy to solve biological puzzles. We also have a Zebra-fish vertebrate animal model established in our lab which we use to understand molecular mechanisms of drug/pesticide/chemicals action.

RNA biology, Genomics and Transcriptomics.

Dr. Ashish Mishra

Delineating Mechanisms Regulating Alternative Splicing Using Functional Genomics Screens.

Circadian Rhythms, Infectious diseases, Proteomics, and Systems Biology

Dr. Sandipan Ray

Our research group is focusing on disease-clock biology, sleep, and circadian medicine using systems biology approaches. A comprehensive understanding of circadian physiology and body clocks has profound implications in translational healthcare research. We are using cutting-edge multi-omics approaches to decipher how circadian clocks regulate immune functions, and thereby the host responses towards infectious organisms (such as Plasmodium). We are also interested to study how targeting clock components could be used to prevent or treat chronic human diseases.

Chromosome Biology and Gene Regulation, Single-Molecule Imaging and Fluroescence Microscopy, Developmental Disorders, Aneuploidy and Cancers

Dr. Gunjan Mehta

We aim to understand the mechanism of cell division/chromosome segregation and gene regulation using cutting-edge single-molecule imaging, fluorescence microscopy, genomics, proteomics, cell and molecular biology and yeast genetics. Our broad research interest lies in studying the functions of chromatin remodelers during meiotic chromosome segregation; understanding the single-molecule dynamics of the mitotic kinases such as aurora kinases, cyclin-dependent kinase 1, polo kinases, checkpoint regulators; exploring the mechanism of epigenetic transcription memory/mitotic bookmarking and understanding how the mitotic to meiotic transition is achieved at the level of 3D genome organization, kinetochore composition and transcriptome. Our basic science research efforts are tailored for developing therapeutics to treat infertility, genetic disorders and cancers in a long run.